The match will start at 1.30 pm IST. The other two matches will be played in Ranchi, and Delhi on 9th and 11th October.
India has not picked a single player from their T20 World Cup squad for the series against Proteas.
The Men-in-Blue, led by Shikhar Dhawan, have several new faces such as Rahul Tripathi, Rajat Patidar, Mukesh Kumar, Shahbaz Ahmed -- in for the ODI series.
On the other hand, South Africa has retained almost the same squad as the last T20I series against India and the upcoming T20 World Cup in Australia. From the T20I squad, they have left out Tristan Stubbs and Rilee Rossouw to bring in Andile Phehlukwayo and Janneman Malan.
Shikhar Dhawan (c), Sanju Samson (wk), Shubman Gill, Shreyas Iyer, Rajat Patidar, Ishan Kishan, Shardul Thakur, Deepak Chahar, Kuldeep Yadav, Avesh Khan, Mohammed Siraj, Rahul Tripathi, Mukesh Kumar, Ruturaj Gaikwad, Shahbaz Ahmed, Ravi Bishnoi
South Africa Squad:
Temba Bavuma (c), Quinton de Kock (wk), Janneman Malan, Aiden Markram, David Miller, Andile Phehlukwayo, Dwaine Pretorius, Wayne Parnell, Keshav Maharaj, Kagiso Rabada, Tabraiz Shamsi, Anrich Nortje, Heinrich Klaasen, Lungi Ngidi, Reeza Hendricks